| Date | Location | Result | |
| Dec 21, 2010 | St. Petersburg, Fla. | Louisville Cardinals 31, SOUTHERN MISS 28 | Box score |
| Nov 26, 2010 | Piscataway, N.J. | Louisville Cardinals 40, RUTGERS 13 | Box score |
| Nov 20, 2010 | Louisville, KY | WVU 17, Louisville Cardinals 10 | Box score |
| Nov 13, 2010 | Louisville, KY | USF 24, Louisville Cardinals 21 | Box score |
| Nov 6, 2010 | Syracuse, NY | LOUISVILLE 28, Syracuse 20 | Box score |
| Oct 30, 2010 | Pittsburgh, PA | PITT 20, LOUISVILLE 3 | Box score |
| Oct 23, 2010 | Louisville, KY | Louisville Cardinals 26, UCONN 0 | Box score |
| Oct 15, 2010 | LOUISVILLE, KY | CINCINNATI 35, Louisville Cardinals 27 | Box score |
| Oct 09, 2010 | LOUISVILLE, KY | Louisville Cardinals 56, MEMPHIS 0 | Box score |
| Oct 02, 2010 | Jonesboro, Ark. | Louisville Cardinals 34, Arkansas St. 24 | Box score |
| Sep 18, 2010 | Corvallis, Ore. | Oregon State 35, Louisville Cardinals 28 | Box score |
| Sep 11, 2010 | Louisville, KY | Louisville Cardinals 23, EKU 13 | Box score |
| Sep 04, 2010 | LOUISVILLE, KY | KENTUCKY 23, Louisville Cardinals 16 | Box score |