| Date | Location | Result | |
| Nov 18, 2000 | Houston, Texas | Louisville 32, Houston 13 | Box score |
| Nov 11, 2000 | Louisville, KY | Louisville 38, Army 17 | Box score |
| Nov 04, 2000 | Hattiesburg, MS | Louisville 49, Southern Miss 28 | Box score |
| Oct 28, 2000 | Louisville, KY | Louisville 35, Tulane 32 | Box score |
| Oct 19, 2000 | Louisville, KY | East Carolina 28, Louisville 25 | Box score |
| Oct 14, 2000 | Louisville, KY | Louisville 38, Cincinnati 24 | Box score |
| Oct 07, 2000 | Birmingham, Ala. | Louisville 38, UAB 17 | Box score |
| Sep 30, 2000 | Louisville, KY | Louisville 41, Connecticut 22 | Box score |
| Sep 23, 2000 | Tallahassee, Fl | Florida State 31, Louisville 0 | Box score |
| Sep 09, 2000 | Louisville, Ky. | Louisville 52, Grambling 0 | Box score |
| Sep 02, 2000 | Louisville, Ky. | Louisville 40, Kentucky 34 | Box score |