| Date | Location | Result | |
| 03/05/16 | Charlottesville, Va. (JPJ) | Virginia 68, Louisville 46 | Box score |
| 3/1/16 | KFC Yum! Center, Louisville,KY | Louisville 56, Georgia Tech 53 | Box score |
| 02-27-16 | BankUnited Center | Coral Gables, Fla. | Miami 73, Louisville 65 | Box score |
| 2/24/16 | Petersen Events Center (Pittsburgh, PA) | Louisville 67, Pittsburgh 60 | Box score |
| 2/20/16 | KFC Yum! Center, Louisville,KY | Louisville 71, Duke 64 | Box score |
| 2/17/16 | KFC Yum! Center, Louisville,KY | Louisville 72, Syracuse 58 | Box score |
| 2/13/16 | Purcell Pavilion | Notre Dame 71, Louisville 66 | Box score |
| 2/8/16 | Cameron Indoor Stadium (Durham, N.C.) | Duke 72, Louisville 65 | Box score |
| 2/6/16 | KFC Yum! Center, Louisville,KY | Louisville 79, BOSTON COLLEGE 47 | Box score |
| 2/1/16 | KFC Yum! Center, Louisville,KY | Louisville 71, North Carolina 65 | Box score |
| 1/30/16 | KFC Yum! Center, Louisville,KY | Virginia 63, Louisville 47 | Box score |
| 01/27/16 | Cassell Coliseum, Blacksburg, Va. | Louisville 91, Virginia Tech 83 | Box score |
| 1/23/16 | McCamish Pavilion, Atlanta, Ga. | Louisville 75, Georgia Tech 71 | Box score |
| 1/20/16 | KFC Yum! Center, Louisville,KY | Louisville 84, Florida State 65 | Box score |
| 1/14/16 | KFC Yum! Center, Louisville,KY | Louisville 59, Pittsburgh 41 | Box score |
| 1/10/16 | Greenville, S.C. | Clemson 66, Louisville 62 | Box score |
| 1/7/16 | PNC Arena - Raleigh, N.C. | Louisville 77, NC State 72 | Box score |
| 1/3/16 | KFC Yum! Center, Louisville,KY | Louisville 65, Wake Forest 57 | Box score |
| 12/26/15 | Rupp Arena - Lexington, KY | Kentucky 75, Louisville 73 | Box score |
| 12/23/15 | KFC Yum! Center, Louisville,KY | Louisville 98, Utah Valley 68 | Box score |
| 12/22/15 | KFC Yum! Center | Louisville 75, Missouri-Kansas City 47 | Box score |
| 12/19/15 | KFC Yum! Center, Louisville, KY | Louisville 78, Western Kentucky 56 | Box score |
| 12/16/15 | KFC Yum! Center, Louisville, KY | Louisville 94, Kennesaw State 57 | Box score |
| 12/12/15 | KFC Yum! Center, Louisville, KY | Louisville 86, Eastern Michigan 53 | Box score |
| 12/5/15 | KFC Yum! Center, Louisville, KY | Louisville 111, Grand Canyon 63 | Box score |
| 12/2/15 | East Lansing, Mich. // Breslin Center | Michigan State 71, Louisville 67 | Box score |
| 11/28/15 | Brooklyn, N.Y. (Barclays Center) | Louisville 77, Saint Louis 57 | Box score |
| 11/24/15 | KFC Yum! Center, Louisville, KY | Louisville 85, St. Francis 41 | Box score |
| 11/21/15 | KFC Yum! Center, Louisville, KY | Louisville 89, North Florida 61 | Box score |
| 11/17/15 | KFC Yum! Center, Louisville,KY | Louisville 87, HARTFORD 52 | Box score |
| 11/13/15 | KFC Yum! Center, Louisville, KY | Louisville 86, Samford 45 | Box score |